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李高

姓名:                     李高
学历:                     博士
职称:                     副教授
职务:                     闽江学院海洋研究院副教授
邮箱:                     ligao2019@mju.edu.cn
研究方向:             阿尔茨海默病,β-淀粉样蛋白,化学生物学,超分子化学
 
教育经历:
2010/09-2014/07       清华大学,化学系,理学学士
2014/09-2019/07       清华大学,化学系,理学博士,导师李艳梅 教授
 
工作经历:
2019/08-至今           闽江学院,海洋研究院,副教授
 
科研项目:
1、纳米运载机器直接清除机体内β-淀粉样蛋白的研究,国家自然科学基金青年项目(22007044,2021-2023)
2、阿尔茨海默病治疗新策略,福建省自然科学基金基础研究与高校产学合作计划面上项目(2020J01864,2020-2023)
 
 
发表论文:
[1]        G. Li, J. Hu, H. Chen, Y.-X. Chen and Y.-M. Li. Cucurbit[8]uril Facilitated Michael Addition for Regioselective Cysteine Modification. Chem. Commun. 2021, 10.1039/D1CC01404H. https://doi.org/10.1039/D1CC01404H
[2]        G. Li, Y. Zhou, W.-Y. Yang, C. Zhang, L. Hong and L. Jia. Inhibitory Effects of Sulfated Polysaccharides from the Sea Cucumber Cucumaria Frondosa against Aβ40 Aggregation and Cytotoxicity. ACS Chem. Neurosci. 2021, 10.1021/acschemneuro.1c00223. https://doi.org/10.1021/acschemneuro.1c00223
[3]        G. Li, W. Y. Yang, W. H. Li, Y. Y. Luo, Y. J. Lim, Y. Li, A. Paul, D. Segal, L. Hong and Y. M. Li. Rational Design of a Cocktail of Inhibitors against Abeta Aggregation. Chem. Eur. J. 2020, 26, 3499-3503. https://doi.org/10.1002/chem.201905621
[4]        G. Li and Y. M. Li. Truncated and Modified A beta Species in Alzheimer's Disease. Prog. Chem. 2020, 32, 14-22. https://doi.org/10.7536/Pc191212
[5]        G. Li, W. Y. Yang, Y. F. Zhao, Y. X. Chen, L. Hong and Y. M. Li. Differential Modulation of the Aggregation of N-Terminal Truncated Abeta using Cucurbiturils. Chem. Eur. J. 2018, 24, 13647-13653. https://doi.org/10.1002/chem.201802655
[6]        G. Li, Z. W. Hu, P. G. Chen, Z. Y. Sun, Y. X. Chen, Y. F. Zhao and Y. M. Li. Prophylactic Vaccine Based on Pyroglutamate-3 Amyloid beta Generates Strong Antibody Response and Rescues Cognitive Decline in Alzheimer's Disease Model Mice. ACS Chem. Neurosci. 2017, 8, 454-459. https://doi.org/10.1021/acschemneuro.6b00336
[7]        G. Li, Y.-X. Chen and Y.-M. Li. New progress in active immunotherapy targeting to amyloid beta. Sci. China: Chem. 2015, 58, 383-389. https://doi.org/10.1007/s11426-014-5310-9
 


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